Endocrine Abstracts

An adrenal incidentaloma is defined as an adrenal mass >1 cm diameter, discovered serendipitously on radiological imaging done for another reason. They are important because a percentage will turn out to be malignant or secrete excess hormones. The aim of the current study was to ascertain if these lesions were being investigated and followed appropriately compared to American Association of Clinical Endocrinologists guidelines. All imaging reports for the calendar year 20...

Recent Endocrine Society guidelines advocate IGF-1, random GH and nadir GH after oral glucose tolerance test (OGTT) for assessment in acromegaly. In our regional centre the 24 h GH profile has also been used partly because of changing IGF-1 assay methodology but also because of concerns that IGF-1 may not adequately reflect partial therapeutic success. We evaluated 58 GH profiles in 35 patients from April 2008 to November 2012 when both GH and IGF-1 assays remained unchanged. ...

Context: Growth of meningiomas has been previously described in patients receiving oestrogen/progestogen therapy.Methods: Case history, laboratory findings, imaging and histology are discussed.Case history: A 45-year-old woman with a known history of 21-hydroxyase deficiency (of the non-salt wasting variety) and long-standing non-adherence with corticosteroid therapy presented to the Endocrine Clinic for follow-up care. She complai...

20% of cases of FIPA have AIP gene mutations. These adenomas are often large and invasive. Our index case presented aged 13 with pituitary apoplexy. Histology showed necrotic tissue. He continued to grow and was 195 cm 4 y later. GH excess was confirmed. After treatment with octreotide and radiotherapy remission was achieved. His first cousin had also been successfully treated for acromegaly. This led to the original familial diagnosis. Subsequently, the c.910C>T, p.R304X ...

It is recommended that all patients with PA who are suitable for surgery should undergo adrenal CT and AVS unless there is a large unilateral adenoma with a completely normal contralateral gland. We reviewed 100 patients diagnosed with PA. AVS was performed in 93. Different lateralisation criteria for AVS were assessed using ROC curve analysis to determine the optimal one for identifying an adenoma. We reviewed the outcomes of adrenalectomy evaluating which pre-operative chara...

Pituitary surgery frequently leads to one or more anterior pituitary hormone deficiencies but the incidence of GH deficiency is unclear. The aim of our study was to establish the incidence of GH deficiency in patients post hypophysectomy. Current NICE guidelines recommend GH replacement in severely GH deficient patients who have one or more other pituitary hormone deficiencies and diminished QoL by AGHDA.Thirty-five patients (M:F 15:20; age range 23&#150...

Pseudoacromegaly or acromegaloidism is used to describe cases where acromegaly-related physical appearance can be observed without any abnormality in the growth hormone (GH) axis. Acromegalic features, in particular coarse facies, together with hypertrichosis, are typical manifestations of one of the pseudoacromegaly conditions: hypertrichosis acromegaloid facial features (HAFF) syndrome. This condition phenotypically overlaps with Cantu syndrome and acromegaloid facial appear...

Pseudoacromegaly or acromegaloidism is used to describe cases where acromegaly-related physical appearance can be observed without any abnormality in the growth hormone (GH) axis. Acromegalic features, in particular coarse facies, together with hypertrichosis, are typical manifestations of one of the pseudoacromegaly conditions: hypertrichosis acromegaloid facial features (HAFF) syndrome. This condition phenotypically overlaps with Cantu syndrome and acromegaloid facial appear...

TSH-secreting pituitary adenomas (TSHomas) are rare. Previously, the reported prevalence was one case per million populations although this is probably an underestimate. A recently published study reported a prevalence of TSHomas in Sweden of 2.8/million inhabitants.Methods/design: Observational study conducted in four tertiary referral centres in Ireland. We retrospectively collected data on the prevalence, demographics, hormonal profile, tumour charact...

Observational studies suggest reduced vitamin D levels are associated with an increased incidence of type 2 diabetes mellitus. We examined the relationship with insulin resistance (assessed using a two-step euglycaemic hyperinsulinaemic clamp technique) in 92 overweight, non-diabetic individuals with no history of cardiovascular disease - mean age 56 years (range 40–77 years), 64% males, 36% females, BMI 30.9 kg/m2 (range 26.4–36.9 kg/m2), fasti...